Further evidence has emerged to link long-term use of proton pump inhibitors with an increased risk of hip fractures.
Data from 79,899 postmenopausal US women showed that chronic PPI use was associated with a 36 per cent increased risk of hip fracture, after adjustment for BMI, physical activity and calcium intake.
The risk was greatest among those who had the longest duration of PPI use, or who had a history of smoking. The latter group recorded a 50 per cent increased risk of hip fracture.
Added to previous evidence from systematic reviews which reached similar conclusions, the authors said the findings provided “compelling evidence” of an association between PPI use and hip fracture. And given PPI use was continuing to increase, it was...
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